Khoi Vinh and the Adobe Team took a bunch of designers for breakfast and asked them about the tools they use. The results, albeit unscientific, still bring terrific insights — such as:

Prototyping is the Wild West. Every team we met with uses a variety of prototyping tools, whether Pixate, Marvel, InVision, Flinto or others. There seems to be little if any standardization; as new tools emerge and teams find that they offer new advantages, designers readily adopt them and set others aside. There’s a feeling that this space has lots of growth and evolution ahead of it.